Matematical modelling in exercise immunometabolism

The design of in-silico models to study the effects of physical exercise on body metabolism presents various challenges since fuel homeostasis is regulated from a multitude of pathways and metabolites in different organs and tissues. Moreover, emerging research suggests that exercise impacts on metabolism as well as on the immune system and that exists a strong interconnection between them, leading to the emergence of a new research area known as “exercise immunometabolism”. This shift in perspective necessitates a transition from models solely focused on exercise metabolism to models encompassing exercise immunometabolism. This talk will provide an overview of the current state-of-the-art in in-silico models of human exercise metabolism and will illustrate modeling of key processes in the exercise immunometabolism perspective.