Talks and Hands-on session

Analysis of glycemic variability during sport (Mationi Maturana F., UNITUBINGEN; Morettini M., UNIVPM)

Glucose is the body’s main energy source, and its regulation is key for metabolic health and longevity. Under normal conditions, glucose is tightly regulated in healthy individuals. However, glucose may present high degrees of variability during exercise, and it is the primary energy source during a high-intensity workout. The advance of continuous glucose monitoring (CGM) technologies in recent years, and its application in non-diabetic populations, have been providing valuable insights on the individuality of glucose regulation, especially during exercise. CGM can be used to tailor nutrition strategies, timing of food intake around a workout, and resting glucose control, to cite a few. In this presentation.

The design of in-silico models to study the effects of physical exercise on body metabolism presents various challenges since fuel homeostasis is regulated from a multitude of pathways and metabolites in different organs and tissues. Moreover, emerging research suggests that exercise impacts on metabolism as well as on the immune system and that exists a strong interconnection between them, leading to the emergence of a new research area known as “exercise immunometabolism”. This shift in perspective necessitates a transition from models solely focused on exercise metabolism to models encompassing exercise immunometabolism. This talk will provide an overview of the current state-of-the-art in in-silico models of human exercise metabolism and will illustrate modeling of key processes in the exercise immunometabolism perspective.